Sleeve gastrectomy is a surgical method used to treat obesity. The aim of this operation is to promote weight loss by reducing the size of the stomach and reducing the feeling of hunger. Gastric Sleeve can improve a number of health problems associated with obesity, but it can also affect metabolic problems such as insulin resistance.

Insulin resistance is a condition in which the body responds less than normal to insulin and can increase the risk of type 2 diabetes. While Gastric Sleeve surgery can improve insulin resistance, in some cases it can make the problem worse. Here are some important points on this topic:

  1. the improvement of insulin resistance: In some obese people, insulin sensitivity can improve as a result of weight loss after Gastric Sleeve. This can reduce the risk of type 2 diabetes. However, this improvement can vary from person to person and is not guaranteed.
  2. worsening insulin resistance: Rapid weight loss as a result of Gastric Sleeve can sometimes worsen insulin resistance. In particular, some people who experience rapid weight loss in the post-operative period may experience an increase in insulin resistance, which can increase the risk of type 2 diabetes.
  3. aftercare and treatment: Aftercare and management of insulin resistance following gastric sleeve surgery is important. Doctors can determine appropriate treatment plans depending on the patient’s condition and metabolic status. Treatment options such as diet, exercise and medication can be used to keep insulin resistance under control.
  4. if you are considering pregnancy: Another important issue related to insulin resistance is planning a pregnancy. If you are considering pregnancy after a Gastric Sleeve, it is important that you have a detailed assessment of insulin resistance and other metabolic risks with a gynaecologist.


The relationship between obesity and insulin resistance is complex, but obesity is an important factor in the development of insulin resistance. Insulin resistance is a condition in which the body’s cells respond less than normal to insulin. Insulin is needed to regulate blood sugar levels and transport glucose (sugar) into cells. Below are some of the main causes that can contribute to insulin resistance due to obesity:

  • Cytokines and Inflammation: Obesity can lead to increased inflammation in the body. This inflammation can result in an elevation of cytokines, substances released by the body’s fat tissue. Cytokines can trigger a series of chemical reactions that enhance insulin resistance, raising the risk of type 2 diabetes.
  • Increase in Fat Tissue: Obesity is associated with excess fat tissue, particularly accumulating in the abdominal area. This surplus fat tissue can raise insulin resistance, as fat cells become less sensitive to insulin, requiring more insulin for proper functioning.
  • Excess Fatty Acids: Obesity can lead to an elevation of circulating fatty acids in the blood. These excess fatty acids serve as building blocks for cell membranes and can cause cells to become less responsive to insulin.
  • Inflammatory Signals: Obesity can trigger increased inflammatory signals in the body. These signals can heighten insulin resistance and prompt the pancreas to produce more insulin.
  • Abnormal Fat Storage: Obesity can result in the storage of fat in inappropriate locations in the body, such as the liver and muscle cells. This can lead to impaired insulin function.


Gastric Sleeve is generally not recommended for people with the following diseases or health conditions:

  • Serious Health Issues: For individuals with severe heart or lung diseases, kidney failure, or other serious health problems, a gastric sleeve surgery is generally not recommended. Such issues can increase the risk of the operation.
  • Active Infections: Individuals with an active infection (such as an acute respiratory infection or urinary tract infection) may need to wait until the infection is fully treated before undergoing the surgery.
  • Mental Health Issues: People with serious mental health problems or those in need of psychiatric treatment should receive appropriate support and treatment before the operation. Postoperative psychological adjustment is also important.
  • Drug or Alcohol Dependency: Individuals with drug or alcohol problems should be carefully examined, as these issues can negatively impact the postoperative recovery process.
  • Severe Nutritional Deficiencies: Gastric sleeve surgery is not recommended for individuals with severe nutritional deficiencies or malabsorption problems, as this procedure can worsen these issues.
  • Pregnancy: Gastric sleeve surgery is not performed during pregnancy. Individuals planning a pregnancy before or after the operation should consult their doctor and, if necessary, plan the surgery for a time after the pregnancy.
  • Age-Related Limitations: Gastric sleeve surgery is generally recommended for individuals between 18 and 65 years old. There are situations where age can influence the risk-to-benefit ratio of the operation.
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